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Sunday, April 29 • 12:05pm - 1:20pm
LUNCH Innovation Theater - Cytokine Signaling & the JAK-STAT Pathway: Role in Rheumatoid Arthritis (RA)

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Sponsored by Lilly

The JAK (Janus kinase) family members serve essential roles as the intracellular signaling effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3, and TYK2 (nonreceptor tyrosine-protein kinase 2), was first described nearly 30 years ago, but the complexities underlying their activation, regulation and pleiotropic signaling functions are still being explored.

At the molecular level, recent studies have greatly advanced our knowledge of the structures and organization of the component pseudokinase and kinase domains within the JAKs, the pathway of JAK activation and, in particular, the role of the pseudokinase domain as a suppressor of the adjacent tyrosine kinase domain’s catalytic activity.

Here, we will review the current knowledge of the physiological functions of Janus kinase and how they may relate to inflammation in Rheumatoid Arthritis. Additionally, we will review highlights of the diversity of regulatory mechanisms utilized by the JAK family to maintain signaling fidelity, and explore possible capabilities of ATP competitive kinase inhibitors.

avatar for Theresa Lawrence Ford, MD

Theresa Lawrence Ford, MD

Medical Director & CEO, North Georgia Rheumatology Group
Theresa Lawrence Ford is Medical Director and CEO of North Georgia Rheumatology Group and an active staff member at Gwinnett Medical Center Hospitals in Lawrenceville, Georgia. She also practices in a single-specialty group in Gwinnett County, Georgia. Dr. Lawrence Ford received her... Read More →

Sunday April 29, 2018 12:05pm - 1:20pm